1140. GATA2 Mutations Are Frequently Identified Among Patients With Myeloid Malignancies Who Develop Invasive Aspergillosis

Acquired ASXL1 mutations are common in patients with inherited GATA2 mutations and correlate with myeloid transformation.

Inherited or sporadic heterozygous mutations in the transcription factor GATA2 lead to a clinical syndrome characterized by non-tuberculous mycobacterial and other opportunistic infections, a severe deficiency in monocytes, B cells and natural killer cells, and progression from a hypocellular myelodysplastic syndrome to myeloid leukemias. To identify acquired somatic mutations associated with m...

Collaborating constitutive and somatic genetic events in myeloid malignancies: ASXL1 mutations in patients with germline GATA2 mutations.

GATA2 and secondary mutations in familial myelodysplastic syndromes and pediatric myeloid malignancies.

Xinan Wang,1 Hideki Muramatsu,1 Yusuke Okuno,1 Hirotoshi Sakaguchi,1 Kenichi Yoshida,2 Nozomu Kawashima,1 Yinyan Xu,1 Yuichi Shiraishi,3 Kenichi Chiba,3 Hiroko Tanaka,3 Shoji Saito,4 Yozo Nakazawa,4 Taro Masunari,5 Tadashi Hirose,6 Shaimaa Elmahdi,1 Atsushi Narita,1 Sayoko Doisaki,1 Olfat Ismael,1 Hideki Makishima,7 Asahito Hama,1 Satoru Miyano,3,8 Yoshiyuki Takahashi,1 Seishi Ogawa,2 and Seiji...

serum galactomannan and diagnosis of invasive aspergillosis in patients with hematologic malignancies, blood and marrow transplantation

introduction: invasive aspergillosis is a major cause of morbidity and mortality in hematologic malignant patients which have received intensive cytotoxic therapy or undergone blood and marrow transplantation (bmt). early clinical and radiological diagnosis of ia is almost impossible and so mortality is very high. the main purpose of our study was to assay the diagnostic value of serum galactom...

Invasive pulmonary aspergillosis in patients with hematologic malignancies: survival and prognostic factors.

BACKGROUND AND OBJECTIVES Despite improvements made in its early diagnosis and effective treatment, invasive pulmonary aspergillosis (IPA) remains a devastating opportunistic infection. In this retrospective study we have reviewed all consecutive cases of IPA diagnosed in adult patients with hematologic malignancies in our center from 1995 to 2000 to determine survival and prognostic factors. ...